| Degree: |
Ph.D., Cellular and Molecular Biology, Baylor College of Medicine, 1993
B.S., Biological Sciences, New York State University, 1988-
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| Laboratory Address: |
Laboratory
CHS BH-569
UNITED STATES
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| Work Address: |
Laboratory
CSH
Los Angeles, CA 90095
UNITED STATES
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| Work Address: |
Office
CHS BH-569
Campus - 711520
CA
UNITED STATES
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Work Phone Number:
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(310)2065197
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Dr. Yibin Wang received his Ph.D. in 1993 from Baylor College of Medicine after completion of his thesis work on liver gene regulation in human genetic disease. In 1998, after post-doctoral training at The Scripps Research Institute and University of California, at San Diego, he joined the faculty of Department of Physiology as assistant professor in University of Maryland School of Medicine, Baltimore, and started to work on signaling mechanisms of heart failure. In 2003, he was promoted to Associated Professor with tenure. In August 2003, Dr. Wang became an Associate Professor with tenure in the School of Medicine at UCLA, Los Angeles, California. Currently, he is a faculty member in the Division of Molecular Medicine at Departments of Anesthesiology and Medicine, and also holds joint appointments at Molecular Biology Institute and Jonsson Comprehensive Cancer Center at UCLA. The main focus of Dr. WangÃÂs research is stress induced signaling mechanism in heart failure. Using molecular genetics and physiological tools, Dr. Wang has demonstrated the pathological role of a number of stress-induced kinases in the development of heart failure and illustrate their potential as therapeutic targets. In addition to his extensive publications in many of the top scientific journals, Dr. Wang also received an Established Investigator Award from American Heart Association, Guident Foundation Visiting Professorship from Case Western University, Ruth L. Kirschstein National Research Service Award from National Institute of Health, and Visiting Scholarship Award from Chinese Natual Science Foundation. He also serves NIH review panels and member of the editorial board of Circulation Research, and Journal of Molecular and Cellular Cardiology.
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Sun Y, Ishibashi M, Seimon T, Lee M, Sharma SM, Fitzgerald KA, Samokhin AO, Wang Y, Sayers S, Aikawa M, Jerome WG, Ostrowski MC, Bromme D, Libby P, Tabas IA, Welch CL, Tall AR Free cholesterol accumulation in macrophage membranes activates Toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin K.
Circ Res..
2009; 104(4):
455-65.
Ruan H, Li J, Ren S, Gao J, Li G, Kim R, Wu H, Wang Y. Inducible and cardiac specific PTEN inactivation protects ischemia/reperfusion injury.
Mol Cell Cardiol..
2009; 46(2):
193-200.
Seimon TA, Wang Y, Han S, Senokuchi T, Schrijvers DM, Kuriakose G, Tall AR, Tabas IA Macrophage deficiency of p38alpha MAPK promotes apoptosis and plaque necrosis in advanced atherosclerotic lesions in mice.
J Clin Invest..
2009; 119(4):
886-898.
Vondriska TM, Wang Y. A new (heat) shocking player in cardiac hypertrophy.
Circ Res..
2008; 103(11):
1194-6.
Lu G, Wang Y. Functional diversity of mammalian type 2C protein phosphatase isoforms: new tales from an old family.
Clin Exp Pharmacol Physiol..
2008; 35(2):
107-12.
Mitchell-Jordan SA, Holopainen T, Ren S, Wang S, Warburton S, Zhang MJ, Alitalo K, Wang Y, Vondriska TM. Loss of Bmx nonreceptor tyrosine kinase prevents pressure overload-induced cardiac hypertrophy.
Circ Res..
2008; 103(12):
1359-62.
Lu G, Ren S, Korge P, Choi J, Dong Y, Weiss J, Koehler C, Chen JN, Wang Y A novel mitochondrial matrix serine/threonine protein phosphatase regulates the mitochondria permeability transition pore and is essential for cellular survival and development.
Genes Dev. .
2007; 21(7):
784-796.
Ruan H, Mitchell S, Vainoriene M, Lou Q, Xie LH, Ren S, Goldhaber JI, Wang Y Gi alpha 1-mediated cardiac electrophysiological remodeling and arrhythmia in hypertrophic cardiomyopathy.
Circulation.
2007; 116(6):
596-605.
Peter PS, Brady JE, Yan L, Chen W, Engelhardt S, Wang Y, Sadoshima J, Vatner SF, Vatner DE Inhibition of p38alpha MAPK rescues cardiomyopathy induced by overexpressed beta(2)-adrenergic receptor, but not beta(1)-adrenergic receptor.
J Clin Invest..
2007; 117(5):
1335-43.
Wang Y. Mitogen-activated protein kinases in heart development and diseases.
Circulation.
2007; 116(12):
1413-23.
Ursitti JA, Petrich BG, Lee PC, Resneck WG, Ye X, Yang J, Randall WR, Bloch RJ, Wang Y Role of an alternatively spliced form of alphaII-spectrin in localization of connexin 43 in cardiomyocytes and regulation by stress-activated protein kinase.
J Mol Cell Cardiol..
2007; 42(3):
572-581.
Vahebi S, Ota A, Li M, Warren CM, de Tombe PP, Wang Y, Solaro RJ p38-MAPK Induced Dephosphorylation of {alpha}-Tropomyosin is Associated With Depression of Myocardial Sarcomeric Tension and ATPase Activity.
Circ Res..
2007; 100(3):
408.
Mitchell, S., Ota, A., Foster, W., Zhang, B., Fang, Z., Patel, S., Nelson, S. F., Horvath, S., and Wang, Y. Distinct gene expression profiles in adult mouse heart following targeted MAP kinase activation.
Physiol Genomics.
2006; 25(1):
50-59.
Eghbali M, Wang Y, Toro L, Stefani E. Heart hypertrophy during pregnancy: a better functioning heart?.
Trends Cardiovasc Med..
2006; 16(8):
285-291.
Glaser ND, Lukyanenko YO, Wang Y, Wilson GM, Rogers TB. JNK activation decreases PP2A regulatory subunit B56alpha expression and mRNA stability and increases AUF1 expression in cardiomyocytes.
Am J Physiol Heart Circ Physiol..
2006; 291(3):
1183-1192.
Xing, W., Zhang, T.C., Cao, D., Wang, Z., Antos, C.L., Li, S., Wang, Y., Olson, E.N., and Wang, D.Z. Myocardin induces cardiomyocyte hypertrophy.
Circ Res.
2006; 98(8):
1089-91.
Chen, H., Yong, W., Ren, S., Shen, W., He, Y., Cox, K.A., Zhu, W., Li, W., Soonpaa, M., Payne, R.M., Franco, D., Field, L.J., Rosen, V., Wang, Y., and Shou W. Overexpression of bone morphogenetic protein 10 in myocardium disrupts cardiac postnatal hypertrophic growth.
J Biol Chem..
2006; 281:
27481-91.
Liu J, Sadoshima J, Zhai P, Hong C, Yang G, Chen W, Yan L, Wang Y, Vatner SF, Vatner DE. Pressure overload induces greater hypertrophy and mortality in female mice with p38alpha MAPK inhibition.
J Mol Cell Cardiol..
2006; 41(4):
680-688.
Ruan, H. Mitchell, S. Goldhaber, J. I. Wang, Y. Ras induced G alpha i signaling in cardiac dysfunction and arrhythmias.
Circulation.
2006; 114:
268-268.
Lu, G., Kang, Y. J., Han, J., Herschman, H. R., Stefani, E., and Wang, Y. TAB-1 modulates intracellular localization of p38 MAP kinase and downstream signaling.
J Biol Chem.
2006; 281:
6087-95.
Devries-Seimon, T., Li, Y., Yao, P. M., Stone, E., Wang, Y., Davis, R. J., Flavell, R., and Tabas, I. Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor.
J Cell Biol..
2005; 171(1):
61-73.
Takimoto E., Champion H.C., Li M., Belardi D., Ren S., Rodriguez E.R., Bedja D., Gabrielson K.L., Wang Y., Kass D.A. Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy.
Nature Medicine.
2005; 11(2):
214-222.
Mansoureh Eghbali, Rupal Deva, Abderrahmane Alioua, Tamara Y. Minosyan, Hongmei Ruan, Wang Y, Ligia Toro and Enrico Stefani Molecular and Functional Signature of Heart Hypertrophy During Pregnancy.
Circulation Research.
2005; 96(11):
1208-1216.
Wang, G., Liem, D. A., Vondriska, T. M., Honda, H. M., Korge, P., Pantaleon, D. M., Qiao, X., Wang, Y., Weiss, J. N., and Ping, P. Nitric oxide donors protect murine myocardium against infarction via modulation of mitochondrial permeability transition .
Am J Physiol Heart Circ Physiol.
2005; 288(3):
1290-1295.
Takimoto E., Champion H.C., Li M., Ren S., Rodriguez E.R., Tavazzi B., Lazzarino G., Paolocci N., Gabrielson K.L., Wang, Y., et al. Oxidant stress from nitric oxide synthase-3 uncoupling stimulates cardiac pathologic remodeling from chronic pressure load.
J Clin Invest. .
2005; 115(5):
1221-31.
Engel, F. B. Schebesta, M. Duong, M. T. Lu, G. Ren, S. X. Madwed, J. B. Jiang, H. P. Wang, Y. Keating, M. T. P38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes.
Genes & Development.
2005; 19( 10):
1175-1187.
Ren, J., Zhang, S., Kovacs, A., Wang, Y., Muslin, A. J. Role of p38a MAPK in cardiac apoptosis and remodeling after myocardial infarction.
J Mol Cell Cardiol.
2005; 38(4):
617-623.
Li M, Georgakopoulos D, Lu G, Hester L, Kass DA, Hasday J, Wang Y. p38 MAP kinase mediates inflammatory cytokine induction in cardiomyocytes and extracellular-matrix remodeling in heart.
Circulation.
2005; 111(19):
2494-2502.
Minamisawa, S., Oshikawa, J., Takeshima, H., Hoshijima, M., Wang, Y., Chien, K. R., Ishikawa, Y., and Matsuoka, R. Junctophilin type 2 is associated with caveolin-3 and is down-regulated in the hypertrophic and dilated cardiomyopathies.
Biochem Biophys Res Commun.
2004; 325(3):
852-6.
Zhang L., Zhu H., Davis J.J., Jacob D., Wu S., Teraishi F., Gutierrez A., Wang Y., Fang B. Lack of p38 MAP Kinase Activation in TRAIL-Resistant Cells is Not Related to the Resistance to TRAIL-Mediated Cell Death.
Cancer Biol Ther.
2004; 3(3):
296-301.
Champion HC, Georgakopoulos D, Takimoto E, Isoda T, Wang Y, Kass DA Modulation of In Vivo Cardiac Function by Myocyte-Specific Nitric Oxide Synthase-3.
Circ Res.
2004; 94(5):
657.
Wang Y., Goldhaber, J. Return of calcium: Manipulating intracellular calcium to prevent cardiac pathologies.
Proc Natl Acad Sci U S A.
2004; 101(16):
5697-8.
Brian G. Petrich, Benjamin C. Eloff, Deborah L. Lerner , Attila Kovacs, Jeffrey E. Saffitz, David S. Rosenbaum and Yibin Wang Targeted Activation of c-Jun N-terminal Kinase in Vivo Induces Restrictive Cardiomyopathy and Conduction Defects.
J Biol Chem .
2004; 279(15):
15330-8.
Minamisawa S, Wang Y, Chen J, Ishikawa Y, Chien KR, Matsuoka R. Atrial chamber-specific expression of sarcolipin is regulated during development and hypertrophic remodeling.
J Biol Chem..
2003; 278(11):
9570-5.
Yang D, Song LS, Zhu WZ, Chakir K, Wang W, Wu C, Wang Y, Xiao RP, Chen SR, Cheng H. Calmodulin Regulation of Excitation-Contraction Coupling in Cardiac Myocytes.
Circ Res..
2003; 92(6):
659.
Christensen G, Gruber PJ, Wang Y, Chien KR Embryonic and neonatal cardiac gene transfer in vivo.
Methods Mol Biol..
2003; 219:
169-78.
Wang Y. Fill a Gab(1) in cardiac hypertrophy signaling: search a missing link between gp130 and ERK5 in hypertrophic remodeling in heart.
Circ Res.
2003; 93:
186-188.
Domsic JK, Wang Y, Mayeda A, Krainer AR, Stoltzfus CM Human immunodeficiency virus type 1 hnRNP A/B-dependent exonic splicing silencer ESSV antagonizes binding of U2AF65 to viral polypyrimidine tracts.
Mol Cell Biol..
2003; 23
(23):
8762-8772.
Isoda T, Paolocci N, Haghighi K, Wang C, Wang Y, Georgakopoulos D, Servillo G, Della Fazia MA, Kranias EG, Depaoli-Roach AA, Sassone-Corsi P, Kass DA Novel regulation of cardiac force-frequency relation by CREM (cAMP response element modulator).
Faseb J..
2003; 17:
144-51.
Champion HC, Georgakopoulos D, Haldar S, Wang L, Wang Y, Kass DA Robust Adenoviral and Adeno-Associated Viral Gene Transfer to the In Vivo Murine Heart: Application to Study of Phospholamban Physiology.
Circulation.
2003; 108(22):
2790-2797.
Shaosong Zhang, Jie Ren, Cindy E. Zhang, Ilya Treskov, Yibin Wang, Anthony J. Muslin Role of 14-3-3-Mediated p38 Mitogen-Activated Protein Kinase Inhibition in Cardiac Myocyte Survival.
Circulation Research.
2003; 93(11):
1026.
Mansouri A, Ridgway LD, Korapati AL, Zhang Q, Tian L, Wang Y, Siddik ZH, Mills GB, Claret FX Sustained activation of JNK-p38 MAP kinase pathways in response to cisplatin leads to Fas ligand induction and cell death in ovarian carcinoma cells.
J Biol Chem. .
2003; 278(21):
19245-19256.
Petrich BG, Molkentin JD, Wang Y. Temporal activation of c-Jun N-terminal kinase in adult transgenic heart via cre-loxP-mediated DNA recombination.
Faseb J..
2003; 17(6):
749.
Zhang S, Weinheimer C, Courtois M, Kovacs A, Zhang CE, Cheng AM, Wang Y, Muslin AJ The role of the Grb2-p38 MAPK signaling pathway in cardiac hypertrophy and fibrosis.
J Clin Invest..
2003; 111(6):
833-841.
Weiss RG, Chatham JC, Georgakopolous D, Charron MJ, Wallimann T, Kay L, Walzel B, Wang Y, Kass DA, Gerstenblith G, Chacko VP An increase in the myocardial PCr/ATP ratio in GLUT4 null mice.
Faseb J..
2002; 16(6):
613-5.
Hoshijima M, Ikeda Y, Iwanaga Y, Minamisawa S, Date MO, Gu Y, Iwatate M, Li M, Wang L, Wilson JM, Wang Y, Ross J, Jr., Chien KR Chronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via in vivo cardiac rAAV gene delivery.
Nat Med..
2002; 8:
864-71.
Sotoudeh M, Li YS, Yajima N, Chang CC, Tsou TC, Wang Y, Usami S, Ratcliffe A, Chien S, Shyy JY Induction of apoptosis in vascular smooth muscle cells by mechanical stretch.
Am J Physiol Heart Circ Physiol.
2002; 282:
1709-1716.
Xu L, Zhan Y, Wang Y, Feuerstein GZ, Wang X Recombinant adenoviral expression of dominant negative IkappaBalpha protects brain from cerebral ischemic injury.
Biochem Biophys Res Commun..
2002; 299(1):
14-17.
Petrich BG, Liao P, Wang Y Using a gene-switch transgenic approach to dissect distinct roles of MAP kinases in heart failure.
Cold Spring Harb Symp Quant Biol..
2002; 67:
429-37.
Petrich BG, Gong X, Lerner DL, Wang X, Brown JH, Saffitz JE, Wang Y. c-Jun N-terminal kinase activation mediates downregulation of connexin43 in cardiomyocytes.
Circ Res..
2002; 91(7):
640-7.
Liao P, Wang SQ, Wang S, Zheng M, Zhang SJ, Cheng H, Wang Y, Xiao RP. p38 Mitogen-activated protein kinase mediates a negative inotropic effect in cardiac myocytes.
Circ Res.
2002; 90(2):
190-6.
Mehrhof FB, Muller FU, Bergmann MW, Li P, Wang Y, Schmitz W, Dietz R, von Harsdorf R In cardiomyocyte hypoxia, insulin-like growth factor-I-induced antiapoptotic signaling requires phosphatidylinositol-3-OH-kinase-dependent and mitogen-activated protein kinase-dependent activation of the transcription factor cAMP response element-binding protein.
Circulation.
2001; 104:
2088-94.
Wang, Y., Goldhaber, J. Signal transduction in cardiac hypertrophy--dissecting compensatory versus pathological pathways utilizing a transgenic approach.
Curr Opin Pharmacol..
2001; 1(2):
134-140.
Liao P, Georgakopoulos D, Kovacs A, Zheng M, Lerner D, Pu H, Saffitz J, Chien K, Xiao RP, Kass DA, Wang Y. The in vivo role of p38 MAP kinases in cardiac remodeling and restrictive cardiomyopathy.
Proc Natl Acad Sci U S A..
2001; 98(98):
12283-8.
Wang Y, Huang S Adenovirus technology for gene manipulation and functional studies.
Drug Discov Today.
2000; 5(1):
10-16.
Balke CW, Wang Y. Distinguishing mechanisms from markers of cardiac contractile dysfunction: more than 1 way to skin the cat of heart failure .
Circulation.
2000; 101:
738-9.
Yue TL, Gu JL, Wang C, Reith AD, Lee JC, Mirabile RC, Kreutz R, Wang Y, Maleeff B, Parsons AA, Ohlstein EH Extracellular signal-regulated kinase plays an essential role in hypertrophic agonists, endothelin-1 and phenylephrine-induced cardiomyocyte hypertrophy.
J Biol Chem..
2000; 275:
37895-37901.
Christensen G, Minamisawa S, Gruber PJ, Wang Y, Chien KR. High-efficiency, long-term cardiac expression of foreign genes in living mouse embryos and neonates.
Circulation.
2000; 101(2):
178-84.
Wang X, McGowan CH, Zhao M, He L, Downey JS, Fearns C, Wang Y, Huang S, Han J. Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest.
Mol Cell Biol..
2000; 20(13):
4543-52.
Garcia GE, Xia Y, Chen S, Wang Y, Ye RD, Harrison JK, Bacon KB, Zerwes HG, Feng L. NF-kappaB-dependent fractalkine induction in rat aortic endothelial cells stimulated by IL-1beta, TNF-alpha, and LPS.
J Leukoc Biol..
2000; 67:
577-84.
Saurin AT, Martin JL, Heads RJ, Foley C, Mockridge JW, Wright MJ, Wang Y, Marber MS The role of differential activation of p38-mitogen-activated protein kinase in preconditioned ventricular myocytes.
Faseb J..
2000; 14:
2237-46.
Luo ZD, Wang Y, Werlen G, Camp S, Chien KR, Taylor P Calcineurin enhances acetylcholinesterase mRNA stability during C2-C12 muscle cell differentiation.
Mol Pharmacol.
1999; 56(5):
886-894.
Minamisawa S, Hoshijima M, Chu G, Ward CA, Frank K, Gu Y, Martone ME, Wang Y, Ross J, Jr., Kranias EG, Giles WR, Chien KR Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy.
Cell.
1999; 99(3):
313-322.
Xia Y, Chen S, Wang Y, Mackman N, Ku G, Lo D, Feng L. RelB modulation of IkappaBalpha stability as a mechanism of transcription suppression of interleukin-1alpha (IL-1alpha), IL-1beta, and tumor necrosis factor alpha in fibroblasts.
Mol Cell Biol. .
1999; 19(11):
7688-7696.
Hertig CM, Kubalak SW, Wang Y, Chien KR Synergistic roles of neuregulin-1 and insulin-like growth factor-I in activation of the phosphatidylinositol 3-kinase pathway and cardiac chamber morphogenesis.
J Biol Chem..
1999; 274(52):
37362-37369.
Wang Y, Huang S, Sah VP, Ross J, Jr., Brown JH, Han J, Chien KR Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family.
J Biol Chem..
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Li M, Georgakopoulos D, Lu G, Hester L, Kass DA, Hasday J, Wang Y p38 MAP kinase mediates inflammatory cytokine induction in cardiomyocytes and extracellular matrix remodeling in heart..
Circulation.
2005; 111(19):
2494-502.
Petrich BG, Eloff BC, Lerner DL, Kovacs A, Saffitz JE, Rosenbaum DS, Wang Y Targeted activation of c-Jun N-terminal kinase in vivo induces restrictive cardiomyopathy and conduction defects..
The Journal of biological chemistry. .
2004; 279(15):
15330-8.
Champion HC, Georgakopoulos D, Takimoto E, Isoda T, Wang Y, Kass DA Modulation of in vivo cardiac function by myocyte-specific nitric oxide synthase-3.
Circulation research.
2004; 94(5):
657-63.
Petrich BG, Wang Y Stress-activated MAP kinases in cardiac remodeling and heart failure; new insights from transgenic studies.
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2004; 14(2):
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H424-33.
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