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Lee Goodglick, M.B.A., Ph.D.
   
 
Affiliations
Member, JCCC Tumor Immunology Program Area

Education:
Degree: M.B.A.
Ph.D.


Contact Information:
Email Address: lgoodglick@mednet.ucla.edu
Work Email Address: lgoodglick@mednet.ucla.edu
Work Address: Office
CHS
Los Angeles, CA 90095
UNITED STATES
Work Address: Laboratory
CHS
Los Angeles, CA 90095
UNITED STATES


Direct Contact Information:
Work Phone Number: (310) 825-9134


Additional Information:

My group is involved in characterizing the molecular mechanism of tumor progression on a global, systems level. Specifically, we are working on 3 aspects of this: 1) Tumor biomarker characterization. We are one of the leading groups identifying and characterizing markers in solid tumors. We are doing this utilizing state-of the art technology of tissue microarrays and mass spectometry; 2) Function of tumor suppressor gene. We are studying a class of putative tumor suppressors in lung and breast cancer which appear to shuttle proteins to lipid raft microdomains. Currently we are defining the normal biology and the role of this family in tumor progression; 3) Nano-scale electronic detection. We are using nanotechnology to produce carbon nanotube-based electronic detectors for protein identification, molecular interactions, and measurement of cellular processes.

Publications:
Krysan K, Merchant FH, Zhu L, Dohadwala M, Luo J, Lin Y, Heuze-Vourc'h N, Pold M, Seligson D, Chia D, Goodglick L, Wang H, Strieter R, Sharma S, Dubinett S COX-2-dependent stabilization of survivin in non-small cell lung cancer. Faseb J. 2004; 18(1): 206-8.
Odabaei G, Chatterjee D, Jazirehi AR, Goodglick L, Yeung K, Bonavida B Raf-1 kinase inhibitor protein: structure, function, regulation of cell signaling, and pivotal role in apoptosis.. Advances in cancer research. . 2004; 91: 169-200.
Wadehra M, Su H, Gordon LK, Goodglick L, Braun J The tetraspan protein EMP2 increases surface expression of class I major histocompatibility complex proteins and susceptibility to CTL-mediated cell death. Clin Immunol. 2003; 107(2): 129-36.
Goodglick LA, Vaslet CA, Messier NJ, Kane AB Growth factor responses and protooncogene expression of murine mesothelial cell lines derived from asbestos-induced mesotheliomas.. Toxicologic pathology. . 1997; 25(6): 565-73.
Goodglick L, Aldrovandi GM, Zack JA, Braun J HIV-1 gp120: An Immunoglobulin Superantigen.. Viral Superantigens 1997; .
Goodglick L, Zevit N, Neshat MS, Braun J Mapping the Ig Superantigen Binding Site of HIV-1 gp120.. Journal of Immunology 1995; 155: 5151-5159.
Goodglick L, Braun J Revenge of the Microbes: Superantigens of the T and B Cell Lineage.. Am. J. Pathology 1994; 144: 623-636.
Shen D, Chang HR, Chen Z, He J, Lonsberry V, Elshimali Y, Chia D, Seligson D, Goodglick L, Nelson SF, Gornbein JA Loss of annexin A1 expression in human breast cancer detected by multiple high-throughput analyses.. Biochemical and biophysical research communications. . 2005; 326(1): 218-27.
Jazirehi AR, Vega MI, Chatterjee D, Goodglick L, Bonavida B Inhibition of the Raf-MEK1/2-ERK1/2 signaling pathway, Bcl-xL down-regulation, and chemosensitization of non-Hodgkin's lymphoma B cells by Rituximab.. Cancer research. . 2004; 64(19): 7117-26.
Dahlin K, Mager EM, Allen L, Tigue Z, Goodglick L, Wadehra M, Dobbs L Identification of genes differentially expressed in rat alveolar type I cells.. American journal of respiratory cell and molecular biology. . 2004; 31(3): 309-16.
Chatterjee D, Goldman M, Braastad CD, Darnowski J, Wyche JH, Pantazis P, Goodglick L Reduction of 9-nitrocamptothecin-triggered apoptosis in DU-145 human prostate cancer cells by ectopic expression of 14-3-3zeta.. International journal of oncology. . 2004; 25(2): 503-9.
Gordon LK, Goldman M, Sandusky H, Ziv N, Hoffman GS, Goodglick T, Goodglick L Identification of candidate microbial sequences from inflammatory lesion of giant cell arteritis.. Clinical immunology (Orlando, Fla.) . 2004; 111(3): 286-96.
Krysan K, Dohadwala M, Luo J, Lin Y, Zhu L, Heuze-Vourc'h N, Goodglick L, Merchant F, Seligson D, Pold M, Strieter R, Sharma S, Dubinett S Cyclooxygenase-2-dependent expression of survivin in non-small cell lung cancer.. Chest. . 2004; 125(5 Suppl): 140S.
Wadehra M, Goodglick L, Braun J The tetraspan protein EMP2 modulates the surface expression of caveolins and glycosylphosphatidyl inositol-linked proteins.. Molecular biology of the cell. . 2004; 15(5): 2073-83.
Wadehra M, Sulur GG, Braun J, Gordon LK, Goodglick L Epithelial membrane protein-2 is expressed in discrete anatomical regions of the eye.. Experimental and molecular pathology. . 2003; 74(2): 106-12.
Christiansen JJ, Rajasekaran SA, Moy P, Butch A, Goodglick L, Gu Z, Reiter RE, Bander NH, Rajasekaran AK Polarity of prostate specific membrane antigen, prostate stem cell antigen, and prostate specific antigen in prostate tissue and in a cultured epithelial cell line.. The Prostate. . 2003; 55(1): 9-19.
Chatterjee D, Han Z, Mendoza J, Goodglick L, Hendrickson EA, Pantazis P, Wyche JH Monocytic differentiation of HL-60 promyelocytic leukemia cells correlates with the induction of Bcl-xL.. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. . 1997; 8(10): 1083-9.
Townsley-Fuchs J, Kam L, Fairhurst R, Gange SJ, Goodglick L, Giorgi JV, Sidell N, Detels R, Braun J Human immunodeficiency virus-1 (HIV-1) gp120 superantigen-binding serum antibodies. A host factor in homosexual HIV-1 transmission.. The Journal of clinical investigation. . 1996; 98(8): 1794-801.
Goodglick L, Felsher DW, Neshat MS, Braun J A novel octamer regulatory element in the VH11 leader exon of B-1 cells.. Journal of immunology (Baltimore, Md. : 1950) . 1995; 154(9): 4546-56.
Berberian L, Goodglick L, Kipps TJ, Braun J Immunoglobulin VH3 gene products: natural ligands for HIV gp120.. Science. . 1993; 261(5128): 1588-91.


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